COMBINATION OF FARNESYL-TRANSFERASE INHIBITION WITH KRAS G12D TARGETING BREAKS DOWN THERAPEUTIC RESISTANCE IN PANCREATIC CANCER

Combination of farnesyl-transferase inhibition with KRAS G12D targeting breaks down therapeutic resistance in pancreatic cancer

Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options.A KRAS mutation can be found knafs lander 3 in up to 90% of all pancreatic tumors, making it a promising therapeutic target.The introduction of new KRAS inhibitors has been a milestone in the history of KRAS mutant tumors; however, therapeutic re

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Mandibular dental arch short and long-term spontaneous dentoalveolar changes after slow or rapid maxillary expansion: a systematic review

ABSTRACT Objective: The aim of this systematic review was to analyze the short and long-term spontaneous dentoalveolar changes of the mandibular dental arch after slow (SME) or rapid (RME) maxillary expansion in the mixed and early apunisw2 permanent dentitions.Methods: An electronic search was performed in the following databases: PubMed/Medline,

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